| Les Zouglous | | | | | |
21 mars 2022  10- 4  Chavanod |
| Les Zouglous |
4 avril 2022 7- 5  Chavanod |
| Aventics |
| | Les Zouglous |
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| CSAGA |
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| Desperagoss FC |
5 avril 2022  10- 3  Pringy |
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| | Desperagoss FC |
| Les Conquissadors | |
21 mars 2022 4- 2  Annexe 3 |
| Les Conquissadors |
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| Gazelec |
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| MTS |
4 avril 2022  20- 0  Cran-Gevrier |
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| | MTS |
| Nextgen | |
21 mars 2022 7- 5  Cran-Gevrier |
| Nextgen |
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| AS Roma l’Orange |
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| Hydrostadium | |
22 mars 2022  5- 3  Pringy |
| Hydrostadium |
5 avril 2022 4- 3  Pringy |
| Rhodo Joli Football Club |
| | Hydrostadium |
| Les Chats Noirs | |
23 mars 2022  3- 5 Meythet |
| Les Gars Lactiques |
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| Les Gars Lactiques |
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| LRG Galoupiot |
6 avril 2022  6- 7  Poisy |
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| | Leroy Merlin |
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| Leroy Merlin |
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4 avril 2022 3- 5  Annexe 1 |
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| | Rhodo Rasta Rocket |
| YBA | |
21 mars 2022  1- 3 Meythet |
| Rhodo Rasta Rocket |
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| Rhodo Rasta Rocket |
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| FC Ditib | |
24 mars 2022  7- 3  Rumilly |
| FC Ditib |
7 avril 2022 8- 2  Rumilly |
| Manchester Cixi |
| | FC Ditib |
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| FC Kosova |
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| Les Sangliers du Marais | |
24 mars 2022  3- 0  Vallières |
| Les Sangliers du Marais |
7 avril 2022 11- 4  Seynod |
| Les Bons Vivants |
| | Les Sangliers du Marais |
| Komercio | |
22 mars 2022  4- 6 Annexe 3 |
| ASCTA 2 |
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| ASCTA 2 |
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| New Team |
5 avril 2022  3- 13  Cran-Gevrier |
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| | Pfeiffer Vacuum |
| Fans de Foot | |
21 mars 2022  5- 5 Annexe 3 Récapitulatif |
| Pfeiffer Vacuum |
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| Pfeiffer Vacuum |
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| FC Eighteen |
4 avril 2022  3- 1  Meythet |
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| | FC Eighteen |
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| QFC |
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